You have to try and find the right holster if you want this to work. Some are comfortable, some are torture devices. You will probably go through a number of them before you find the right one, if you get that far.
You also have to give it some time, and not just give up. Its going to take a while for your body to get used to it and for things to settle in. It will feel strange and off for a bit too until you begin to get used to it.
Walking is going to feel strange at first and like you have a ball and chain on one leg. That will pass.
The best holsters Ive found are the Desantis "Leather Ankle Holster", and the Galco Ankle Glove. Both are comfortable enough to wear while walking around all day.
If you buy one of those Unkle Mikes nylon holsters, just take it home and throw it right in the thrash.
If you wear dress, or low cut shoes, you may want to get the garter strap. I normally wear mid high hikers, and they help you out a couple of ways.
One, they can take the weight load off of your ankle so you don't have to crank the holsters strap down so thight, as the holster rests on top of the shoe and you don't need the garter.
And two, they keep the gun up a little higher, and its less likely to poke out when you sit and cross or extend your legs. Ive heard some say they wear a second sock that they pull up over the holster. Ive never done that or felt the need.
Pants make a big difference, both in comfort and access. I wear full cut pants all the time anyway, so I didn't have any trouble. If you wear skinny jeans, or more pants that are more fitted, especially through the legs, you're going to want to find something else.
Shorts? Uh...No.
Your going to want to figure out your best options at drawing the gun and practice that a lot. There are a couple of basic methods, and your ability to move freely and easily is really going to come into play here. '
My old 642 in the Desantis.